TTX

  1. It has a high solubility because

  2. Hyrdoxyl

  3. The water bonded with the OH / HO bonds and that made it soluble. Ionic / polar bonds

  4. The channels contract and relax the muscles.

  5. The sodium potassium pump.

  6. The inside of the cell membrane.

  7. When the voltage across the membrane is below -90 mv the sodium ion channel is essentially inactive.
    8.

  8. There are more H (hydroxl) groupds so they are polar / basic.

  9. Over time the number of open channels go down so TTX is blocking the channels.
    11.